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Zaključak

CRPS je kompleksno i višedimenzionalno stanje koje se karakteriše teškim, postojanim bolom
i raznolikim drugim kliničkim manifestacijama. Nedavna istraživanja doprinijela su našem
razumijevanju patofiziologije, dijagnoze i liječenja CRPS. Multidisciplinarni pristup koji obuhvata
farmakološke, nefarmakološke i intervencione modalitete neophodan je za sveobuhvatan pristup
liječenju. Potrebna su dalja istraživanja kako bi se razjasnili osnovni mehanizmi i optimizovale

terapijske strategije za pacijente sa CRPS.

Abstract

Complex Regional Pain Syndrome (CRPS) is a disease that significantly reduces functional ability and is characterized by
pronounced, persistent pain, which often affects one limb. Despite advances in research and treatment, CRPS remains
a challenge to diagnose and treat effectively. CRPS mostly affects people between the ages of 40 and 60, with a higher
prevalence in women. The pathophysiology of CRPS includes a complex interplay of neuroimmunological, neuroplastic
and nociceptive mechanisms. CRPS is characterized by a diverse spectrum of clinical manifestations that reflect a complex
interaction of sensory, motor, autonomic, and inflammatory processes. The diagnosis of CRPS requires a multimodal
approach that integrates clinical evaluation, diagnostic criteria, and additional testing. The Budapest criteria represent
standardized diagnostic criteria, including sensory, motor, vasomotor and sudomotor symptoms. The therapeutic approach
to CRPS includes a variety of therapeutic modalities aimed at alleviating pain, improving function, and improving quality
of life. A multimodal interdisciplinary approach including pharmacological, non-pharmacological and interventional
modalities is necessary for comprehensive treatment. Further research is needed to elucidate the underlying mechanisms
and optimize therapeutic strategies for patients with CRPS. This review paper aims to provide a thorough analysis of CRPS,
incorporating current research findings to advance understanding and inform evidence-based treatment strategies.

Keywords: Complex Regional Pain Syndrome, CRPS, chronic pain, neuropathic pain, diagnosis, treatment

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