Page 61 - GALENIKA MEDICAL JOURNAL

HSV–1 najčešće uzrokuje Gingivostomatitis, Herpes labialis i herpetični keratitis, dok HSV–2 obično
uzrokuje genitalne lezije. Virus se prenosi bliskim kontaktom sa oboljelom osobom, ali je moguća
transmisija nakon kontakta i sa asimptomatskom osobom. Nakon primarne infekcije, HSV ostaje
u latentnom stanju u odgovarajućem ganglionu do eventualne ponovne infekcije. Komplikacije i
infekcije sa težom kliničkom slikom su encefalitis, meningitis, neonatalna infekcija i generalizovana
infekcija kod imunokompromitovanih pacijenata. Mukokutane infekcije manifestuju se nakupinama
malih bolnih vezikula na eritemnoj osnovi. Dijagnoza se postavlja klinički, a može se potvrditi
kultivacijom, PCR analizom, direktnom imunofluorescencijom ili serološki. Liječenje je simptomatsko,

upotrebom antivirusnih lijekova, a terapijski efekat se postiže njihovom pravovremenom i
adekvatnom primjenom.

Abstract

Infections caused by the Herpes simplex virus belong to highly contagious diseases, where humans are the reservoir of
this virus, and the infection is transmitted through direct contact with an infected person. Human Herpes simplex (HS) virus
comprises two types of virus, Herpes simplex 1 (HSV-1) and Herpes simplex 2 (HSV-2), which cause numerous primary and
recurrent infections of the skin and mucous membranes. Commonly HSV-1 causes Herpes labialis, herpetic stomatitis and
keratitis. HSV-2 usually causes genital herpes, and is transmitted primarily through direct sexual contact with the lesions
of an infected person. However, it is estimated that most genital herpes infections are transmitted by individuals who are
asymptomatic at the time of transmission. The disease is one of the most common viral infections in humans, and Herpes
simplex virus infection can be a significant clinical problem in infants, the elderly, and immunocompromised patients.
Timely antiviral therapy leads to adequate rehabilitation and prevention of complications caused by the Herpes simplex
virus. The paper presents the most important information about the causative agent of the infection, the mechanism of
origin and manifestation of the disease, diagnosis and timely application of antiviral therapy that will prevent possible
complications caused by the Herpes simplex virus.

Keywords: Herpes simplex virus, clinical picture, therapy, prevention

Literatura Sep;108(3):876-9.
9. Groves MJ. Genital Herpes: A Review. Am Fam Physician. 2016 Jun
1;93(11):928-34.
1. Karadaglić Đ, Krstić Lj. Bolesti koje se prenose polnim kontaktom.
Beograd: Medicinska knjiga; 1995; 57-67. 10. Prevention. Genital herpes–CDC fact sheet (detailed). Available
2. Strick LB, Wald A. Diagnostics for herpes simplex virus: is PCR the new at:https://www.cdc.gov/std/herpes/stdfact-herpes-delatiled.ttm.
gold standard? Mol Diagn Ther. 2006;10(1):17-28. 11. McQuillan G, Kruszon-Moran D, Flagg EW, Paulose-Ram R. Prevalence of
Herpes Simplex Virus Type 1 and Type 2 in Persons Aged 14-49: United
3. Workowski KA, Bolan GA; Centers for Disease Control and Prevention. States, 2015-2016. NCHS Data Brief. 2018 Feb;(304):1-8.
Sexually transmitted diseases treatment guidelines, 2015. MMWR
Recomm Rep. 2015 Jun 5;64(RR-03):1-137. Erratum in: MMWR Recomm 12. Yeung-Yue KA, Brentjens MH, Lee PC, Tyring SK. Herpes simplex viruses
Rep. 2015 Aug 28;64(33):924. 1 and 2. Dermatol Clin. 2002 Apr;20(2):249-66.
4. Gnann JW Jr, Whitley RJ. CLINICAL PRACTICE. Genital Herpes. N Engl J 13. Lautenschlager S, Eichmann A. Urethritis: an underestimated
Med. 2016 Aug 18;375(7):666-74. clinical variant of genital herpes in men? J Am Acad Dermatol. 2002
5. Marques AR, Cohen JI. Herpes simplex. In: Goldsmith LA, Katz SI, Feb;46(2):307-8.
Gilchrist BAt all. Fitzpatricks Dermatology in General Medicine, 8th edit. 14. Ashley RL, Wald A. Genital herpes: review of the epidemic and potential
New York: mcGraw Hill Medicine; 2012: 2367-82. use of type-specific serology. Clin Microbiol Rev. 1999 Jan;12(1):1-8.
6. Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet. 2001 15. Guerry SL, Bauer HM, Klausner JD, Branagan B, Kerndt PR, Allen BG,
May 12;357(9267):1513-8. Bolan G. Recommendations for the selective use of herpes simplex
virus type 2 serological tests. Clin Infect Dis. 2005 Jan 1;40(1):38-45.
7. Wolf K, Johnson R. Saavedra A. Fitzpatrick clinical dermatology. Seventh
Edition. 2013.Viral disease of skin and mucosa. 661-2. 16. Nath P, Kabir MA, Doust SK, Ray A. Diagnosis of Herpes Simplex Virus:
8. Camazine B, Antkowiak JG, Nava ME, Lipman BJ, Takita H. Herpes Laboratory and Point-of-Care Techniques. Infect Dis Rep. 2021 Jun
2;13(2):518-39.
simplex viral pneumonia in the postthoracotomy patient. Chest. 1995

REVIJALNI RADOVI Galenika Medical Journal, 2023; 2(5):56-60. 59