Page 20 - GALENIKA MEDICAL JOURNAL

Zaključak

U ovom istraživanju utvrđena je značajna razlika između protoka krvi u horiokapilarisu kod pacijenata
koji nemaju DR i onih koji imaju promjene u smislu DR, sa ili bez DME. Ovi rezultati imaju značaja u
pogledu istraživanja OCTA kao dijagnostičkog i prognostičkog sredstva za dijabetičku makulopatiju.
Takođe, utvrđena je razlika između gustine prokrvljenosti u površnom kapilarnom pleksusu, ali u
pravcu obrnutom od očekivanog, što je najvjerovatnije uzrokovano prosječnom starošću ispitanika

u ispitivanim grupama. S obzirom na pomenuto, ovo istraživanje predstavlja uvod u planirana
dalja istraživanja na većem broju ispitanika, koji će doprinijeti pogledu na OCTA kao novu tehniku
za vizualizaciju i kvantifikaciju vaskularnih promjena u smislu ranog dijagnostikovanja subkliničke
dijabetičke retinopatije, kao i praćenju postojećih promjena na retini kod osoba oboljelih od dijabetes
melitusa tip 2.

Abstract

Introduction: Diabetic Retinopathy (DR) is a common microvascular complication of diabetes mellitus. Optical Coherence
Tomography Angiography (OCTA) is a new method for visualizing the microvasculature of the retina and choroid, which is
based on detecting the movement of circulating erythrocytes.

Objective: To present OCTA findings in patients with diabetes mellitus with different microvascular changes to diagnose
diabetic retinopathy before the onset of clinical signs of the disease, as well as to monitor changes in clinically visible
retinopathy, with or without Diabetic Macular Edema (DME).

Methods: In this study, OCTA findings in three groups of selected subjects were compared - 5 patients with Non-
Proliferative Diabetic Retinopathy (NPDR) without DME, 5 patients with NPDR and DME, and 5 patients with diabetes but
without NPDR and DME.

Results: Patients in all three groups showed decreased vessel diameter (VD) in the foveal, parafoveal, and perifoveal
segments of the Superficial Capillary Plexus (SCP) and Deep Capillary Plexus (DCP) and an increase in Foveal Avascular Zone
(FAZ).

Conclusion: OCT angiography represents a new technique for visualizing and quantifying vascular changes and is
increasingly important in the early diagnosis of subclinical retinopathy, as well as in monitoring existing changes in the
retina in people with type 2 diabetes mellitus.

Keywords: diabetic retinopathy, diabetic macular edema, optical coherence tomography angiography

Literatura 4. Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin
Epidemiologic Study of diabetic retinopathy. XIV. Ten-year incidence
and progression of diabetic retinopathy. Arch Ophthalmol. 1994
1. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin Sep;112(9):1217-28.
epidemiologic study of diabetic retinopathy. III. Prevalence and risk of 5. Engerman RL, Kern TS. Retinopathy in animal models of diabetes.
diabetic retinopathy when age at diagnosis is 30 or more years. Arch Diabetes Metab Rev. 1995 Jul;11(2):109-20.
Ophthalmol. 1984 Apr;102(4):527-32.
6. Hammes HP, Lin J, Renner O, Shani M, Lundqvist A, Betsholtz C, et al.
2. Wong TY, Cheung CM, Larsen M, Sharma S, Simó R. Diabetic Pericytes and the pathogenesis of diabetic retinopathy. Diabetes. 2002
retinopathy. Nat Rev Dis Primers. 2016 Mar 17;2:16012. Oct;51(10):3107-12.
3. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, 7. Wong TY, Cheung CM, Larsen M, Sharma S, Simó R. Diabetic
et al; American Diabetes Association. Diabetic retinopathy. Diabetes retinopathy. Nat Rev Dis Primers. 2016 Mar 17;2:16012.
Care. 2003 Jan;26(1):226-9.

18 DOI: 10.5937/Galmed2306013R